Pseudoephedrine and the rare risk of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS)
Postulated role of pseudoephedrine in causing PRES and RCVS
Pseudoephedrine is a sympathomimetic agent widely used to alleviate nasal congestion by constricting blood vessels in the nasal passages. It is often found in combination with antihistamines and antipyretics for treating symptoms of the common cold or allergies. Despite its long-standing use and efficacy, there have been reported cases associating pseudoephedrine with posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS). These neurological conditions are rare but serious, characterized by cerebral ischemia and often manifesting with symptoms such as headaches, visual disturbances, mental changes, seizures, and brain edema.
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